Week 4: Summer Immersion

 This is Ruoxin Li. This week I worked in the lab to learn AAV manufacturing. AAV (Adeno-associated virus) is non-enveloped virus that can be used to deliver DNA to target cells. For example, in the case of A1AT deficiency patient, if they are ZZ genome mutations, they can get AAV with gene that codes for anti-trypsin protein. In this way, AAV can constantly produce the protein to prevent the lung from being damaged by the trypsin.  Nowadays, there are more than 150 clinical trials of AAV. It is important to learn how to make AAV first and then figure out a way to maximize AAV's applications. 

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